Wellmune WGP Marathon Runner Stress Study Clinical Trial
Wellmune is a component of MonaVie Mmun Juice. This summary is taken from the December 19, 2009 press release on www.nutraceuticalsworld.com. You can find a pdf of the full Wellmune marathon runner stress study here.
Wellmune WGP Reduced Cold-Like Symptoms 
Wellmune WGP, from Biothera, Eagan, MN, significantly reduced upper respiratory tract infection symptoms in marathon runners while increasing vigor and overall health, according to a study published in the December issue of the Journal of Sports Science and Medicine.
The double-blind, placebo-controlled study included 75 runners (35 men, 40 women) ages 18-53 (mean age 36 years) from the 2007 Carlsbad Marathon in California. During the four-week period following the marathon, subjects consumed Wellmune WGP.
Wellmune WGP is Generally Recognized As Safe (GRAS) by FDA. Clinical research demonstrates that Wellmune WGP activates neutrophils, the most abundant immune cell in the body, to more quickly recognize and kill foreign challenges. Previous published research shows that physical and psychological stress reduces key immune system components, weakening immune defenses and rendering individuals more susceptible to health challenges.
“The data demonstrates the ability of Wellmune WGP to naturally enhance the body’s immune system, resulting in broad protection from stress-induced health challenges,” said Shawn Talbott, PhD, research director for SupplementWatch, Inc., and the study’s principal investigator. “These health benefits aren’t limited to elite athletes; average consumers under daily stress can strengthen their immune systems with Wellmune WGP.”
“The study results provide further support for companies that are marketing or formulating foods and beverages with Wellmune WGP,” said Richard Mueller, Biothera’s CEO. “Consumers want products that deliver real health benefits, and clinical studies consistently demonstrate that Wellmune WGP is safe and efficacious.”
The physical health results demonstrated a significant decrease in upper respiratory tract infection (URTI) symptoms at two and four weeks for subjects taking 250 mg of Wellmune WGP daily. The most common URTI symptoms reported were sore throat, stuffy or runny nose and cough.
When asked how the supplement regimen was affecting their overall health, participants consuming 250 mg of Wellmune WGP daily reported 38% higher scores compared with the placebo group. In addition, the Wellmune subjects reported significantly better scores on a variety of mood states, including a 22% increase in vigor (with 500 mg of Wellmune), 48% reduction in fatigue, 38% reduction in tension and a 38% reduction in confusion.
The study employed a Profile of Mood States (POMS) questionnaire, a validated psychometric test that measures six moods states (vigor, fatigue, tension, confusion, depression and anger) using 65 adjective-based intensity scales.
“The marathoners taking Wellmune WGP experienced fewer symptoms of upper respiratory tract infections so their energy levels and general sense of wellness were higher than the placebo group,” said Dr. Talbott. “Wellmune WGP supports both physical health and a general sense of well-being.”
This summary is taken from the Wellmune corporate website.
Marathon Runner Stress Study
In a double-blind, placebo-controlled study, marathon runners taking Wellmune WGP® reported significant physical and psychological health benefits.
The physical health results demonstrated a significant decrease in upper respiratory tract infection (URTI) symptoms at two and four weeks for subjects taking 250 mg of Wellmune WGP daily. Sixty-eight percent of runners in the placebo group reported URTI symptoms at 2 weeks compared with only 32% for the group taking Wellmune WGP. At four weeks, 24% of the placebo group reported URTI symptoms compared with 8% of the Wellmune WGP group.
When asked how the supplement regimen was affecting their overall health, participants consuming 250 mg of Wellmune WGP daily reported 38% higher scores compared with the placebo group. In addition, the Wellmune subjects reported significantly better scores on a variety of mood states, including a:
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22% increase in vigor**
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48% reduction in fatigue
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38% reduction in tension
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38% reduction in stress-related confusion
**500 mgs of Wellmune WGP
Study Design:
The double-blind, placebo-controlled study included 75 marathon runners (35 men, 40 women) ages 18-53 (mean age 36 years) who were recruited from the 2007 Carlsbad Marathon in California. During the four-week period following the marathon, subjects consumed a placebo or Wellmune WGP, a natural carbohydrate that activates key immune cells to more quickly recognize and kill foreign challenges.
The study measured the psychological states of the participants using a Profile of Mood States (POMS) questionnaire. The POMS profile method is a validated psychometric test that measures six primary moods states (vigor, fatigue, tension, confusion, depression and anger). The POMS profile has been used in more than 2,900 health studies.
Monavie (M)mūn™ and the principal ingredient Wellmune® clinically proven to enhance innate immune cells.
Optimize your body’s natural defenses. MonaVie (M)mūn™ is a beneficial blend of 19 fruits and Wellmune®—clinically shown to promote proper immune function. Formulated with antioxidant rich MVao2, ™ a proprietary complex featuring the superfruits açai and maqui, this delicious juice helps protect your body year round. It’s your daily defense for a healthier life.
The Premier Açai Blend®
MonaVie (M)mūn is a delightful fusion of 19 fruits, which were specifically chosen for their ability to nutritionally support your immune health and overall well being.
Açai, maqui, grape, apple, acerola, aronia, black currant, elderberry, cranberry, blood orange, sea buckthorn, pear, blueberry, cupuaçu, strawberry, baobab, lingonberry, bilberry, and camu camu.
Key Benefits
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Supports your immune system, which helps safeguard your body against potentially harmful microorganisms.
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Helps optimize proper immune function.
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Promotes and maintains an overall sense of good health and well being.
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Benefits young and old alike—ages four and up.
Essential Facts
Safeguard. Optimize. Shield. The SOS approach of MonaVie (M)mūn arms your body against everyday challenges.
– Safeguards your health. Just like the daily practices of wearing a seatbelt or brushing your teeth help protect your body, drinking four ounces of MonaVie (M)mūn every day helps support your overall health.
– Optimizes your natural defenses. MonaVie (M)mūn supports your immune system with a unique complex carbohydrate that’s supported by seven clinical studies and more than $250 million in research and development.
– Shields your body. Everyday challenges such as poor eating habits, heavy workloads, and lack of sleep and exercise can take a toll on your health. MonaVie (M)mūn supports your immune system, a complex network of specialized cells that helps shield against potentially harmful microorganisms.
Wellmune and Immune Function
Elite athletes, such as marathon runners, place a significant amount of physical stress on their bodies, which can tax their health. Similar to other burdens on the body (e.g., lack of sleep, poor diet, emotional strain), exercise stress can compromise your immune system.
In a four week study* examining the effects of Wellmune in marathon athletes, participants who took Wellmune reported an improvement in their feelings of well being and in the maintenance of their overall health.
* Journal of Sports Science and Medicine (2009) 8, 509-515
Why Consume MonaVie Mmun Daily?
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Daily stressors take a toll on your immune system.
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Immune cells have a very short lifespan and are replenished daily.
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MonaVie Mmun helps immune cells function at optimum capacity.
What is Wellmune?
Wellmune® is a natural ingredient that activates a large population of immune cells to defend the body against a wide range of foreign challenges. Derived from the cell walls of a proprietary strain of yeast, this unique gluco polysaccharride acts as a biological response modifier.
As the immune system evolved, it became very adept at killing yeast and fungi by recognizing certain molecules that commonly occur on the cell surface of these challenges. Wellmune is one such recognition molecule.
Wellmune binds to specific receptors (CR3) on neutrophils, the most abundant immune cell in the body, and activates or enhances its anti-microbial activity, including immune cell migration to the site of a challenge (chemotaxis) and increased killing of intruders (phagocytosis and oxidative burst).
The molecular structure of Wellmune, with its beta 1,3/1,6 branch points, is responsible for its unique biological activity.
Research
Clinical research consistently demonstrates the ability of Wellmune® to naturally enhance human immune responses and provide protection from health challenges related to physical and lifestyle stress. Double-blind, placebo-controlled studies involving marathoners, firefighters and other individuals with stressful lifestyles found that Wellmune reduces incidence of upper respiratory tract infection symptoms and improves a sense of overall health.
These findings are not surprising based on the large body of published research demonstrating Wellmune® unique mechanism of action. Scientists understand how Wellmune works in the body at a cellular and intracellular level, making it perhaps the most researched functional ingredient in the world.
Equally important, research also documents what Wellmune® does not do: stimulate the immune system. Other immune health ingredients stress the immune system in ways that may be harmful over time. Wellmune® enhances natural immune function and is safe for daily consumption.
Patents
Biothera’s superior intellectual property and dominant patent position provides customers with confidence in the safety, efficacy and long-term availability of the company’s products. Biothera has more than 40 U.S. patents and patents pending, with additional filings in more than 20 countries that protect:
Matter of composition
Manufacturing processes
Applications
Biothera has successfully defended its patents in U.S. courts against infringement. The company intends to continue to vigorously protect its intellectual property rights.
About Wellmune®
Wellmune® is a functional food, beverage and dietary supplement ingredient available worldwide through Biothera and its distributors. This natural compound (gluco polysaccharide) is isolated from the cell walls of a proprietary strain of yeast. Wellmune® is Generally Regarded As Safe (GRAS) under U.S. Food and Drug Administration regulations. It also is Kosher, HALAL, non-allergenic and GMO-free. Numerous peer-reviewed studies support the safety and efficacy of Wellmune® which is the culmination of years of research and a technology investment of more than $250 million.
New MonaVie (M)mūn™ Fruit Descriptions
1. Juçara
Juçara is also an açai palm tree, which is native to South America. A drink made with this form of açai is widely consumed by the inhabitants of the northern region of Brazil. The juçara açai palm produces dark purple fruit that looks similar to a grape or blueberry. This fruit is rich in polyphenol antioxidants. According to laboratory testing, the juçara açai fruit has a strong ORAC value when compared to other fruits and vegetables.
2. Maqui berry
(pronounced: mä-key) Maqui is a plant that grows in Chile and western Argentina. The deep purple maqui berry has been used traditionally for a variety of benefits including support for immune health and vitality. The maqui berry contains powerful antioxidants including polyphenols and anthocyanins, which help protect against the damaging effects free radicals can have on our cells and support healthier aging.
3. Baobab
The baobab tree is native to the tropical lands of Africa. The elongated oval shaped baobab fruit (like a potato) has a hard shell covered with soft yellowish-gray fur. The literature is abundant for its traditional use as a food. The most edible and frequently consumed part of this popular African fruit is the inner pulp. The pulp is commonly eaten raw or mixed with milk or water to make a drink. Vitamin C is one of the most prominent nutrients found in the baobab fruit.
4. Black currant
Black currant is native to Europe and northern Asia. A variety of black currant is also found in North America. It is cultivated for its fruit, which is used in jelly, pudding, tarts and in making spirits. Black currant fruit is a source of vitamin C, an essential vitamin with antioxidant properties. It has been studied for its anthocyanin content; an antioxidant that gives this berry its distinctive color.
5. Blood orange
In Sicily, the “blood” orange gained its nickname because of its ruby flesh that contains the red pigment, anthocyanin, a strong antioxidant. Sicilian Red oranges deliver more than instant gratification in the form of flavor and sweetness. They also contain nutritional and health supporting properties. Blood oranges have been used in home remedies for centuries. They are known for their vitamin C content.
6. Elderberry
Elderberries are small, dark berries that grow in clusters on elder bushes (also called elderberry trees). There are many different varieties of elderberry trees. Elderberry bushes are a hardy plant growing native in many climates in Europe and North America. The berries are said to have many nutritional benefits. Elderberries contain vitamin C, which is commonly used to support the immune system. Elderberries also have anthocyanins, antioxidants which are responsible for giving many red and purple fruits their color.
7. Strawberry
It is commonly believed that strawberries were cultivated back in Ancient Rome. In the 13th century, strawberries were used in France as a medicinal herb. The most common strawberry cultivated today, a hybrid variety known as the garden strawberry from Europe, is noted for its intense flavor and large size. The bright red aggregate fruit contains antioxidants and other beneficial phytonutrients.
8. Lingonberry
Lingonberry is a creeping, evergreen, sub-shrub native to North America, Europe, and Asia. It is widely distributed in arctic, alpine, and northern temperate forest regions. The fruit is bright to dark red, strong flavored, and tart. Lingonberries contain beneficial nutrients such as vitamins and antioxidant polyphenol compounds.
9. Sea Buckthorn
Sea Buckthorn is a hardy deciduous shrub native to Asia and Northwestern Europe. Other countries who are cultivating this shrub include Canada, Germany, Japan, and northern European countries. It has been produced for centuries in Europe and Asia as a foodstuff and traditional remedy. The shrub produces yellow-orange to red berries that contain vitamins and other nutrients such as vitamins A, C, and E, and other nutritional compounds.
SOURCES: Monavie.com; MonaVie Product Quick Reference Guide; Wellmune.com
We are at this time in these countries and adding more every year
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In many personal testimonials people say they are living well, doing away with ailments and arthritis pain, have more energy, are reducing muscle and joint aches, increasing sexual appetite and performance, reducing stress, improving digestion, and are left feeling great all day, every day.
Dr. Nicholas Perricone appeared on The Oprah Winfrey show to promote his book “The Perricone Promise: Look Younger-Live Longer in Three Easy Steps” in which he lists the Ten Super Foods to Rejuvenate the Body. He rated the Acai Berry as #1, calling it one of the most nutritious and powerful foods in the world and the Oprah Winfrey website lists the acai berry the same way.